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Precursor-directed fungal generation of novel halogenated chaetoglobosins with more preferable immunosuppressive action |
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| Authors: | Ge Hui Ming Yan Wei Guo Zhi Kai Luo Qiong Feng Rui Zang Le Yun Shen Yan Jiao Rui Hua Xu Qiang Tan Ren Xiang |
| Institution: | Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093, China. |
| Abstract: | Precursor-fed cultivation of endophytic Chaetomium globosum 1C51 afforded nine novel "unnatural" halogenated chaetoglobosins including those with more preferable immunosuppressive activity. |
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