A concise asymmetric synthesis of the ADE fragment of nakadomarin A |
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Authors: | Ahrendt Kateri A Williams Robert M |
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Affiliation: | Department of Chemistry, Colorado State University, Fort Collins, CO 80523-1872, USA. |
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Abstract: | The ADE fragment of nakadomarin A has been synthesized in nine linear steps from commercial material. The key transformation is an asymmetric azomethine ylide [1,3]-dipolar cycloaddition to establish the AD-spirocyclic system containing three of the four stereocenters of the natural product. [reaction: see text] |
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