| Synthesis of Chiral Aminophenols Based on Proline and Their Application in Enantioselective Addition of Diethylzinc to Aldehydes |
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| 引用本文： | 张雅文 陆新华 陆忠娥 葛健锋 沈宗旋. Synthesis of Chiral Aminophenols Based on Proline and Their Application in Enantioselective Addition of Diethylzinc to Aldehydes[J]. 中国化学, 2003, 21(7): 950-954. DOI: 10.1002/cjoc.20030210745 |
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| 作者姓名： | 张雅文 陆新华 陆忠娥 葛健锋 沈宗旋 |
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| 作者单位： | [1]DepartmentofChemistryandChemicalEngineering,SuzhouUniversity,Suzhou,Jiangsu215006,China [2]DepartmentofChemistryandChemicalEngineering,SuzhouUniversity,Suzhou,Jiangsu215006,China；DepartmentofMaterialandEngineering,SuzhouUniversity,Suzhou,Jiangsu215006,China |
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| 基金项目： | Project supported by the Key Laboratory of Organic Syntheses,Jiangsu Province(No.T2109102). |
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| 摘 要： | Three 2-{（3R, 7aS )-1, 1-disubstituted-tetrahydro-lH-pyrrolo [ 1,2- c ] [ 1,3 ] oxazol-3-yl} phenols have been synthesized from salicylaldehyde and amino alcohols derived from L-proline, and used as ligands in enantioselective addition of diethylzinc to aldehydes, the ee values of obtained secondary alcohols were found in the range of 0-90%.
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| 关 键 词： | 合成 手性氨基苯酚 脯氨酸 应用 对映选择加成 二乙基锌有机化合物 乙醛 2－{（3R 7aS）－1 1－取代基－四羟基－lH－吡咯并[1 2－c][1 3]唑－3烷基}苯酚 |
Synthesis of Chiral Aminophenols Based on Proline and Their Appli-cation in Enantioselective Addition of Diethylzinc to Aldehydes |
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| GE,Jian-Feng SHEN,Zong-Xuan ZHANG,Ya-WenLU,Xin-Hua LU,Zhong-E. Synthesis of Chiral Aminophenols Based on Proline and Their Appli-cation in Enantioselective Addition of Diethylzinc to Aldehydes[J]. Chinese Journal of Chemistry, 2003, 21(7): 950-954. DOI: 10.1002/cjoc.20030210745 |
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| Authors: | GE Jian-Feng SHEN Zong-Xuan ZHANG Ya-WenLU Xin-Hua LU Zhong-E |
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| Affiliation: | GE,Jian-Feng SHEN,Zong-Xuan ZHANG,Ya-WenLU,Xin-Hua LU,Zhong-E Department of Chemistry and Chemical Engineering,Suzhou University,Suzhou,Jiangsu 215006,China Department of Material and Engineering,Suzhou University,Suzhou,Jiangsu 215006,China |
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| Abstract: | Three 2-{(3R, 7aS)-1, 1-disubstituted-tetrahydro-1H-pyrrolo [1,2-c][1,3]oxazol-3-yl} phenols have been synthesized from salicylaldehyde and amino alcohols derived from L-proline, and used as ligands hi enantioselective addition of diethylzinc to aldehydes, the ee values of obtained secondary alcohols were found in the range of 0-90%. |
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| Keywords: | aminophenol 2-{(3R 7aS )-1 1-disubstituted-tetrahydro-1H-pyrrolo[1 2-c][1 3]oxazol-3-yl}-phenols enantio-selective addition diethylzinc |
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