Expeditious synthesis of water-soluble, monolayer-protected gold nanoparticles of controlled size and monolayer composition |
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Authors: | Manea Flavio Bindoli Cristiano Polizzi Stefano Lay Luigi Scrimin Paolo |
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Institution: | Department of Chemical Sciences and ITM-CNR, University of Padova, Padova Section, 35131 Padua, Italy. |
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Abstract: | A protocol is reported for the preparation of water-soluble, thiol-protected Au nanoparticles (Au-MPC) where dioctylamine is used as a stabilizing agent when the gold cluster is formed using the two-phase Brust and Schiffrin procedure. The amount of amine controls the size of the nanoparticles in the 1.9-8.9 nm diameter range. The final stabilization of the gold clusters by addition of functionalized thiols is performed under very mild conditions compatible with most biomolecules. The procedure is suitable for a wide variety of functional groups present in the thiol and allows one to use thiol mixtures with a precise control of their composition in the monolayer. As a proof of principle, examples of nanoparticles protected with thiols comprising functional groups ranging from polyethers, saccharides, polyamines and ammonium ions are reported. |
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