NaBArF4‐Catalyzed Oxidative Cyclization of 1,5‐ and 1,6‐Diynes: Efficient and Divergent Synthesis of Functionalized γ‐ and δ‐Lactams |
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Authors: | Bo‐Han Zhu Cai‐Ming Wang Hong‐Yu Su Long‐Wu Ye |
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Abstract: | An efficient NaBArF4‐catalyzed oxidative cyclization of readily available 1,5‐ and 1,6‐diynes has been developed. Importantly, this transition metal‐free oxidative catalysis proceeds via a presumable Lewis acid‐catalyzed SN2’ pathway, which is distinct from the relevant oxidative rhodium and gold catalysis. This method leads to the facile and practical construction of a diverse range of synthetically useful γ‐ and δ‐lactams in mostly good to excellent yields with broad substrate scope. |
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Keywords: | oxidation cyclization homogeneous catalysis alkynes heterocycles |
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