Synthesis,crystal structures and anticancer activities of two decavanadate compounds |
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Authors: | Yan-Tuan Li Chun-Yuan Zhu Zhi-Yong Wu Man Jiang Cui-Wei Yan |
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Institution: | (1) Marine Drug & Food Institute, Ocean University of China, 5 Yushan Road, 266003 Qingdao, People’s Republic of China;(2) Key Lab. Marine Drug, Chinese Minist. Educ., Ocean University of China, Qingdao, People’s Republic of China;(3) College of Marine Life Science, Ocean University of China, 266003 Qingdao, People’s Republic of China |
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Abstract: | Two ammonium decavanadate(V) compounds, (H2tmen)3V10O28·6H2O (1) and (H2en)3V10O28·2H2O (2), where H2tmen and H2en represent the doubly protonated N,N,N′,N′-tetramethylethylenediammonium ion and doubly protonated ethylenediammonium ion, respectively, have been synthesized and
structurally characterized by elemental analyses, spectroscopic (i.r., e.s.r.) studies, and single-crystal X-ray diffraction.
Both crystal structures reveal the presence of the V10O28]6− cluster anions, doubly protonated diammonium cations, and lattice water molecules. Hydrogen bonds assemble these two compounds
to form three-dimensional networks. The in vitro anticancer activity against A549 and P388 tumor cells lines has also been
determined by the MTT-based assay, and the results suggest that both compounds can inhibit proliferation of these two kinds
of tumor cells. |
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