Mass spectra of gliclazide drug at various ion sources temperature |
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Authors: | M A Zayed F A Nour El-Dien M F Hawash M A Fahmey |
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Institution: | (1) Chemistry Department, Faculty of Science Cairo University, Giza, A.R. Egypt;(2) Nuclear Physics Department, N.R.C. Atomic Energy Authority, Cairo, 13759, A.R. Egypt |
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Abstract: | Gliclazide (GL, C15H21N3O3S) drug is used as non-insulin-dependant diabetes mellitus. The drug was investigated using thermal analysis (TA) measurements
(TG/DTG) and electron impact mass spectral (EI–MS) fragmentation at 70 eV techniques. The mass spectra of GL at different
values of ion source temperatures (400, 416, 425, and 440 K) are recorded and investigated. Semiempirical MO calculation,
using PM3 procedure, has been carried out on neutral molecule and positively charged species. These calculations included
bond length, bond order, bond strain, partial charge distribution, ionization energy, and heats of formation (ΔH
f). PM3 procedure provides a basis for fine distinction among sites of initial bond cleavage, which is crucial to the rationalization
of subsequent fragmentation of the molecule. The primary fragmentation pathway in both TA and MS (at different values of ion
source temperature) is initiated by S–N bond rupture. TA and DTG show one main weight loss at 250.38 °C and four peaks at
271.6, 360.99, 427.93 and 479.17 °C in DTA, which may be attributed to various fragments. Also, the rate constant (K′) of thermal degradation has been tested isothermally at 210 and 600 °C. The calculated rate values are 9.6 × 10−3 and 0.33 × 10−3 s−1, respectively, and discussed. In MS, the effect of ion source temperature on mass spectral fragmentation processes is discussed
on the basis of energy considerations using quasi equilibrium theory. |
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