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A simple microwave-assisted preparation of 2-bromo-1-alkenes from 1-alkynes using the LiBr-TMSCl-TEAB reagent system |
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| Authors: | Anon BunritSomsak Ruchirawat Charnsak Thongsornkleeb |
| Affiliation: | a Program on Chemical Biology, The Center of Excellence on Environmental Health, Toxicology and Management of Chemicals, Chulabhorn Graduate Institute, Vibhavadee-Rangsit Highway, Bangkok 10210, Thailand b Laboratory of Organic Synthesis, Chulabhorn Research Institute, Vibhavadee-Rangsit Highway, Bangkok 10210, Thailand c Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, Vibhavadee-Rangsit Highway, Bangkok 10210, Thailand |
| Abstract: | 2-Bromo-1-alkenes are cleanly and conveniently generated in good yields and selectivities via microwave-assisted hydrobromination of 1-alkynes using a combination of lithium bromide (LiBr), chlorotrimethylsilane (TMSCl), and tetraethylammonium bromide (TEAB) in acetonitrile (MeCN). |
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