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Creating planar electrode systems for biosensors |
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| Authors: | A A Parshintsev E S Soldatov V V Kashin V V Kolesov S V Krupenin A N Reshetilov |
| Institution: | 1. Faculty of Physics, Moscow State University, Moscow, 119991, Russia 2. Kotel’nikov Institute of Radio Engineering and Electronics, Russian Academy of Sciences, Moscow, 125009, Russia 3. Skryabin Institute of Biochemistry and the Physiology of Microorganisms, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russia |
| Abstract: | A planar topology for a nanoelectronic transducer based on glucose oxidase is designed for use in an enzymatic biosensor. Electromigration is used to create 5-nm gaps in Au nanowires. A method for the chemical modification of a silica surface with epoxysilane is developed and glucose oxidase is immobilized on the surface of a support by means of linking molecules. A technique for biochemical signal registration is developed. The eelectric response of the biosensor with glucose in a test solution and the dependence of this response on the glucose concentration are investigated. |
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