Synthesis of new amidophosphite ligand and its application in Ir-catalyzed asymmetric hydrogenation of heterocyclic compounds |
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| Authors: | S E Lyubimov D V Ozolin A A Pavlov I N Fedorova V S Velezheva V A Davankov |
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| Institution: | 1. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, 119991, Moscow, Russian Federation
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| Abstract: | A new chiral amidophosphite ligand was synthesized and tested in the iridium-catalyzed hydrogenation of heterocyclic compounds. The enantioselectivity of hydrogenation of 2-methylquinoline considerably increases when piperidine hydrochloride is used as an additive. The hydrogenation reaction of 8-methyl-2,4,5,6-tetrahydro-1H-pyrazino3,2,1-jk]carbazole by metal complex was conducted for the first time to prepare enantiomerically enriched antidepressant Pyrazidol. |
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