| Synthetic Studies of Didemnaketals Analogue-Construction of the Intermediate (3S,5S,6R)-3,7-Dimethyl-5,6,7-trihydroxy-octanal |
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| 引用本文： | Yan Xing JIA, Bin WU, Ping Zhen WANG, Yong Qiang TU(Department of Chemistry and National Laboratory of Applied Organic Chemistry,Lanzhou University Lanzhou 730000). Synthetic Studies of Didemnaketals Analogue-Construction of the Intermediate (3S,5S,6R)-3,7-Dimethyl-5,6,7-trihydroxy-octanal[J]. 中国化学快报, 2000, 11(6): 509-510 |
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| 作者姓名： | Yan Xing JIA Bin WU Ping Zhen WANG Yong Qiang TU(Department of Chemistry and National Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000) |
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| 作者单位： | Department of Chemistry and National Laboratory of Applied Organic Chemistry，Lanzhou University Lanzhou 730000 |
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| 摘 要： | TheDidemnaketalsAandBhavebeenreportedtobesignificantinhibitorstoHlV-protease'.Inconnectionwiththetotalsynthesisofthiskindofcompounds,ourrecentresearchinterestisfocusedontheirsyntheticstudiesaswellassynthesisofananaloguel,whichincorPoratedthekeyspiroketalmoietyofthedidemnaketalsAandB.Basedontheretrosyntheticconsideration(Schemcl),thelinearintermediate2wouIdbeconstructedfrom3and4.Furthermore,4wouldbesynthesizedfrom( )-PuIegone5.Wehereinreportedastereoselectivesyntheticprocedureforthe(3S,5S…
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Synthetic Studies of Didemnaketals Analogue-Construction of the Intermediate (3S,5S,6R)-3,7-Dimethyl-5,6,7-trihydroxy-octanal |
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| Yan Xing JIA,Bin WU,Ping Zhen WANG,Yong Qiang TU. Synthetic Studies of Didemnaketals Analogue-Construction of the Intermediate (3S,5S,6R)-3,7-Dimethyl-5,6,7-trihydroxy-octanal[J]. Chinese Chemical Letters, 2000, 11(6): 509-510 |
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| Authors: | Yan Xing JIA Bin WU Ping Zhen WANG Yong Qiang TU |
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| Abstract: | An efficient and stereoselective synthetic procedure for (3S,5S,6R)-3,7-dimethyl-5,6,7-trihydroxy-octanal derivative, the intermediate for synthetic of the HIV-active didemnaketals analogue, was developed via a series of reactions from the natural ( )-Pulegone. In this approach.an efficient diastereoselective reaction of the epoxides 8 and 9 with PCC has been accomplished. |
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| Keywords: | Didemnaketals stereoselective synthesis diastereoselective reaction |
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