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Tosylmethylisocyanide (TosMIC) [3+2] cycloaddition reactions: A facile Van Leusen protocol for the synthesis of the new class of spirooxazolines,spiropyrrolines and Chromeno[3,4-c]pyrrols
Authors:Ahmad Shaabani  Heshmatollah Sepahvand  Ayoob Bazgir  Hamid Reza Khavasi
Institution:Faculty of Chemistry, Shahid Beheshti University, G. C., P. O. Box 19396-4716, Tehran, Iran
Abstract:The reactivity and chemo-, regio- and diastreo-selectivity of tosylmethyl isocyanides (TosMIC) are investigated in Van Leusen type 3 + 2] cycloaddition reactions with the various activate cyclic ketones and double C/>C bonds in the synthesis of spirooxazolines, spiropyrrolines and chromeno3,4-<em>c</em>]pyrrols in good to excellent yields under catalyst-free conditions without any activation at ambient temperature.</td>
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Keywords:Tosylmethylisocyanide  Van Leusen protocol  Spirooxazolines  Spiropyrrolines  Chromeno[3  4-c]pyrrols
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