Technetium(I) tricarbonyl complexes: potential precursors of the radiopharmaceuticals. Part II: phenethylbiguanide (phenformin) |
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Authors: | L Fuks E Gniazdowska P Ko?miński I Herdzik-Koniecko |
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Institution: | (1) Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland |
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Abstract: | The radiosynthesis of 99mTc]-phenformin (99mTc]-1-phenethylbiguanide) complex and its suitability as precursor of the radiopharmaceuticals for the tumor imaging was assessed.
Radiochemical purity of the 99mTc]-complex was determined using radio-TLC and was studied by the HPLC with radiochemical detection, while its stability in
challenge experiments. The results show, that due to the sufficient stability and lipophilicity of the complex, it fulfills
our expectations for promising radiopharmaceutical precursor not only for the diagnostic agent, but also for the drug suitable
for the oncological Auger electron therapy. |
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