Synthesis of 3,6-diazahomoadamantane |
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| Authors: | A. I. Kuznetsov I. M. Senan A. Kh. Shukkur I. A. Azzheurova T. M. Serova |
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| Affiliation: | 1.Lomonosov Academy of Fine Chemical Technology,Moscow,Russia;2.Institute of Physiologically Active Substances,Russian Academy of Sciences,Chernogolovka, Moscow oblast,Russia |
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| Abstract: | Condensation of 1-phenylsulfanylpropan-2-one with 1,3,6,8-tetraazatricyclo[4.4.1.13,8]dodecane gave 1-phenylsulfanyl-3,6-diazahomoadamantan-9-one which was reduced to 1-phenylsulfanyl-3,6-diazahomoadamantane, and the latter was subjected to desulfurization over Raney nickel to obtain previously unknown 3,6-diazahomoadamantane. Heating of 9-phenyl-3,6-diazahomoadamantan-9-ols with Raney nickel resulted in reduction of the hydroxy group with formation of 9-phenyl-3,6-diazahomoadamantanes. |
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