Spectroscopic and Photophysical Properties of Protonated Forms of Some Fluoroquinolones in Solutions |
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| Authors: | A V Polishchuk E T Karaseva T B Emelina V E Karasev |
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| Institution: | (1) Department of Chemistry, University of Turku, FI-20014 Turku, Finland;(2) Institute of Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, pr. 100-let Vladivostoku, 159, 690022 Vladivostok, Russia;(3) Department of Physics, Tampere University of Technology, PO Box 692, FIN-33101 Tampere, Finland; |
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| Abstract: | Electronic absorption and fluorescence spectra of ciprofloxacin, norfloxacin, enoxacin, pefloxacin and nalidixic acid in aqueous
solutions were investigated. The time-resolved fluorescence spectra were measured and interpreted. The changes of the luminescence
spectra and electron structure of the compounds under study are explained by different degrees of the spin-orbital interaction
caused by nitrogen heteroatoms lone pairs effect. Possible ways of the protonation process for naphtyridine and quinolone
rings with different substitutions are discussed. The photophysical behavior of FQs was studied using density functional theory
(DFT) calculations. |
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