| 螯合剂与牛血清白蛋白竞争镉作用的研究 |
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| 引用本文： | 李荣昌,陈宝卫,王夔,吴永慧,王祥云.螯合剂与牛血清白蛋白竞争镉作用的研究[J].高等学校化学学报,1986,7(7):571. |
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| 作者姓名： | 李荣昌 陈宝卫 王夔 吴永慧 王祥云 |
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| 作者单位： | 1. 北京医科大学药物药理实验室;
2. 北京大学技术物理系 |
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| 摘 要： | 研究了十一种螯合剂使结合在牛血清白蛋白(BSA)上的镉活动化的能力。由凝胶色谱法测得的F值将螯合剂活动镉的能力排成以下顺序:DTP>EDTA>EGTA>NTA>TRIEN>;PEN>CYS>HIS>SA氨羧络合剂型配体能有效地与BSA竞争,而且它们的lgF与lgKCdL间有一线性关系。
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| 收稿时间： | 1985-04-16 |
Studies of the Competition for Cadmium Ion Between Chelating Agents and Bovine Serum Albumin |
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| Li Rongchang,Chen Baowei,Wang Kui,Wang Xiangyun,Wu Yonghui.Studies of the Competition for Cadmium Ion Between Chelating Agents and Bovine Serum Albumin[J].Chemical Research In Chinese Universities,1986,7(7):571. |
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| Authors: | Li Rongchang Chen Baowei Wang Kui Wang Xiangyun Wu Yonghui |
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| Institution: | 1. Institute of Pharmaceutical Science Beijing Melical Univrsity, Beijing;
2. Department of Technical Physics Peking University, Beijing |
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| Abstract: | Eleven chelating agents were studied for their ability to mobilize the cadmium bound to bovine serum albumin (BSA).Thc parameter F,which is defined as the ratio between the percentages of Cd bound to BSAin the presence and absence of chelating agents,can be used as the criterion for the estimation of the mobilizing ability of chelating agents.The Fvalues determined experimentally lead to a mobilizing ability sequence DTPA>EDTA>EGTA>NTA>TRIEN>PEN>CYS>HIS>SAThe polyaminopolycarboxylate type chelators mobilize Cd effectively.Alinear relationship is found between lgFand lgKCJL (conditional stability constant of the cadmium chelates) for all the chelators except the mcrcapto-compounds.The anomalous behavior of the mercaplo-chelate agents is discussed. |
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