Solid-phase chemoenzymatic synthesis of C-sialosides |
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| Authors: | Baytas Sultan N Wang Qun Karst Nathalie A Dordick Jonathan S Linhardt Robert J |
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| Affiliation: | Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York 12180, USA. |
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| Abstract: | The chemoenzymatic regioselective acylation of Neu5Ac followed by SmI2-mediated C-glycosylation on a solid support is described for five C-glycosides. This method should facilitate the construction of combinatorial libraries of inhibitors of neuraminidase activity and hemagglutinin interaction as potential antiviral agents. |
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