The progress and perspective of strategies to improve tumor penetration of nanomedicines |
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| Authors: | Jiang Hu Xinwei Yuan Fei Wang Huile Gao Xilin Liu Wei Zhang |
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| Institution: | 1. Department of Orthopedics, Sichuan Provincial People''s Hospital & Sichuan Academy of Medical Sciences & Affiliated Hospital of University of Electronic Science and Technology, Chengdu 610072, China;2. Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy Sichuan University, Chengdu 610041, China |
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| Abstract: | Tumor penetration is important fo r effectively tumor targeting drug delivery.Recently,many researches are published to overcome the barriers that restrict tumor penetration and improve drug delivery efficiency.In the mini review,we first analyzed the barriers influence the tumor penetration,including tumor microenvironment barriers,nanoparticle properties,and interaction barriers between tumor and nanoparticles.To overcome the barrier,several strategies are developed,including modulating tumor microenvironment,changing particle size,transcytosis enabled tumor penetration,cell penetrating peptide modification and overcoming binding site barrier,which could effectively improve tumor penetration,and finally enhance tumor treatment outcome. |
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| Keywords: | Tumor penetration Tumor microenvironment Size changeable Cell penetrating peptide Nanoparticles |
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