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Access to multi-functionalized oxazolines via silver-catalyzed heteroannulation of enamides with sulfoxonium ylides |
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| Authors: | Rui-Hua Liu Qi-Chao Shan Ya Gao Teck-Peng Loh Xu-Hong Hu |
| Institution: | 1. Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China;2. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore |
| Abstract: | Disclosed herein is an efficient Ag-catalyzed 4 + 1] heteroannulation reaction of enamides with α-carbonyl sulfoxonium ylides. The diastereoselective transformation provides a practical access to a diverse range of multi-functionalized oxazoline derivatives. The synthetic utility of the resultant tetra-substituted oxazolines is further demonstrated by a series of useful manipulations into valuable building blocks of pharmaceutical relevance. |
| Keywords: | Enamides Sulfoxonium ylides Oxazolines Silver catalysis Heteroannulation |
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