Facile synthesis of metal-polyphenol-formaldehyde coordination polymer colloidal nanoparticles with sub-50 nm for T_1-weighted magnetic resonance imaging |
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Authors: | Jing Qin Guohai Liang Bingxi Feng Gen Wang Na Wu Yonghui Deng Ahmed A. Elzatahry Abdulaziz Alghamdi Yongxi Zhao Jing Wei |
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Affiliation: | 1. The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China;2. College of Biophotonics, South China Normal University, Guangzhou 510631, China;3. Department of Chemistry, Fudan University, Shanghai 200433, China;4. Materials Science and Technology Program, College of Arts and Sciences, Qatar University, PO Box 2713, Doha, Qatar;5. Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia |
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Abstract: | Plant polyphenol-based coordination polymers(CPs) with ultra-small particle size and tailorable compositions are highly desired in biomedical applicatio ns,but their synthesis is still challenging due to the sophisticated coordination assembly process and unavoidable self-oxidation polymerization of polyphenol. He rein,a general ligand covalent-modification mediated coordination assembly strategy is proposed for the synthesis of water-dispersible CPs with tunable metal species(e.g., Gd,Cu,Ni,Zn,Fe)and ultra-small diameter(8.6-37.8 nm) using nontoxic plant polyphenol(e.g..tannic acid,gallic acid) as a polymerizable ligand.Polyphenol molecules react with formaldehyde firstly,which can effectively retard the oxidation induced self-polymerization of polyphenol and lead to the formation of metal ions containing CPs colloidal nanoparticles.These ultrafine nanoparticles with stably chelated metal io ns are highly water dispersible and thus advantageous for bioimaging.As an example,ultra-small Gd contained CPs exhibit higher longitudinal relaxivity(r_1=25.5 L mmol ~1 s ~1) value with low r_2/r_1(1.19) than clinically used Magnevist(Gd-DTPA,r_1=3.7 L mmol ~1 s ~1).Due to the enhanced permeability and retention effect,they can be further used as a positive contrast agent for T_1-weighted MR imaging of tumour. |
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Keywords: | Coordination polymer Nanoparticle Self-assembly Plant polyphenol Contrast agent |
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