Polysaccharide-based supramolecular drug delivery systems mediated via host-guest interactions of cucurbiturils |
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| Authors: | Yiyun Gao Yan Gao Yuanfu Ding Huaping Tan Aihua Zou Shengke Li |
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| Institution: | 1. School of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, China;2. Shanghai Key Laboratory of Functional Materials Chemistry, State Key Laboratory of Bioreactor Engineering and Institute of Applied Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China;3. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China;4. College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China |
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| Abstract: | With excellent biocompatibility and biodegradability,natural polysaccharides and their derivative s have exhibited great potential in constructing drug delivery ve hicles for tissue engineering and therapeutics.Cucurbitn]uril(CB n])-mediated reversible crosslinking of polysaccharides possess intrinsic stimuliresponsiveness towards competitive guests and have been extensively investigated to fabricate various particles and hydrogels for multiple stimuli-re sponsive drug release by incorpo ration with other stimuli including photo,redox,and enzyme.Through host-guest interactions between CB6] and aliphatic diamines,functional tags covalently connected with CB6] can be readily anchored into polysaccharidebased hydrogels,realizing multiple functionalization.The rheological prope rty and drug release profile of polysaccharide-based supramolecular hydrogels can be facilely tuned through CB 8]-mediated dyna mic homo or hetero crosslinking of polysaccharides and/or other polymers.In this review,we introduce and summarize recent progress regarding polysaccharide-based supramolecular drug delivery systems mediated via host-guest interactions of CB6] and CB8],covering both bulk hydrogels and particular systems.At the end,possible utilization of CB7]-based host-guest interactions in constructing polysaccharide-based drug delivery systems and future perspectives of this research direction are also discussed. |
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| Keywords: | Host-guest interaction Polysaccharides Hydrogel Drug delivery Tissue engineering |
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