| 三氮唑偶联的阿拉伯糖苷化白杨素衍生物的合成与表征 |
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| 引用本文： | 景临林,范小飞,马慧萍,樊鹏程,贾正平.三氮唑偶联的阿拉伯糖苷化白杨素衍生物的合成与表征[J].化学研究,2013(5):466-469. |
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| 作者姓名： | 景临林 范小飞 马慧萍 樊鹏程 贾正平 |
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| 作者单位： | 1. 兰州军区兰州总医院 药剂科,甘肃 兰州,730050
2. 兰州军区兰州总医院 药剂科，甘肃 兰州 730050; 兰州大学 药学院，甘肃 兰州 730000 |
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| 基金项目： | 国家自然科学基金(81202458)． |
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| 摘 要： | 利用点击化学,由三乙酰阿拉伯糖叠氮化物和炔丙基取代白杨素分子通过Cu催化的1,3-环加成反应得到了一种三氮唑阿拉伯糖苷化白杨素衍生物,利用核磁共振光谱、红外光谱、电子轰击质谱对其结构进行了表征,并利用元素分析测定了其组成.结果表明,所得合成产物为目标化合物.
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| 关 键 词： | 白杨素 点击化学 糖基化三唑 合成 表征 |
Synthesis and characterization of glycosylated chrysin derivative linked with 1,2,3-triazole |
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| JING Linlin
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FAN Xiaofei
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MA Huiping
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FAN Pengcheng
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JIA Zhengping.Synthesis and characterization of glycosylated chrysin derivative linked with 1,2,3-triazole[J].Chemical Research,2013(5):466-469. |
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| Authors: | JING Linlin FAN Xiaofei MA Huiping FAN Pengcheng JIA Zhengping |
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| Institution: | JING Lin-lin;FAN Xiao-fei;MA Hui-ping;FAN Peng-cheng;JIA Zheng-ping;Department of Pharmacy,Lanzhou General Hospital of Lanzhou Command of CPLA;Department of Medicinal Chemistry,Lanzhou University; |
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| Abstract: | Based on ＂click chemistry＂, a glycosylated arabinoseyltriazole chrysin derivative was synthesized in good yield by way of the copper-mediated 1,3 dipolar cyctoaddition reaction of ti racetylarabinose azide and alkynyl-substituted chrysin. The structure of as-synthesized product was characterized by means of nuclear magnetic resonance spectrometry, infrared spectrome- try, and electron ionization-mass spectrometry, and its elemental composition was determined by elemental analysis. It was found that as synthesized product is the target compound. |
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| Keywords: | chrysin click chemistry glycosyltriazole synthesis characterization |
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