Nickel-catalysed aromatic Finkelstein reaction of aryl and heteroaryl bromides |
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| Authors: | Cant Alastair A Bhalla Rajiv Pimlott Sally L Sutherland Andrew |
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| Institution: | WestCHEM, School of Chemistry, The Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK. |
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| Abstract: | A fast and efficient nickel-catalysed iodination reaction of aryl and heteroaryl bromides has been developed. The transformation was found to be general for a wide range of substrates and was used for the synthesis of iodo-PK11195, an imaging agent of Alzheimer's disease and iniparib, a compound used in the treatment of breast cancer. |
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