A water soluble Cu(I)-NHC for CuAAC ligation of unprotected peptides under open air conditions |
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| Authors: | Gaulier Christelle Hospital Audrey Legeret Bertrand Delmas Agnès F Aucagne Vincent Cisnetti Federico Gautier Arnaud |
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| Affiliation: | Institut de Chimie de Clermont-Ferrand, CNRS UMR 6296, Clermont-Université, 24 Ave des Landais, F-63177 Aubière, France. |
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| Abstract: | A reducing agent-free version of CuAAC able to operate under open air conditions is reported. A readily-synthesizable, hydrophilic and highly stable Cu(I)-NHC allows the clean ligations of unprotected peptides comprising sensitive side chains, at millimolar concentrations. |
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