Novel N-aryl and N-heteroaryl sulfamide synthesis via palladium cross coupling |
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| Authors: | Alcaraz Lilian Bennion Colin Morris James Meghani Premji Thom Stephen M |
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| Institution: | Department of Medicinal Chemistry, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leics, LE11 5RH, United Kingdom. lilian.alcaraz@astrazeneca.com |
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| Abstract: | A novel and efficient synthesis of N-aryl and N-heteroaryl sulfamides via an intermolecular palladium-catalyzed coupling process has been developed. The reactions proceeded with good to excellent yields and were tolerant of a wide range of functional groups. reaction: see text] |
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