Optimization of the ultrasound-assisted synthesis of allyl 1-naphthyl ether using response surface methodology |
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Authors: | Fernandes João Paulo dos Santos Carvalho Bruno Simões Luchez Cibele Venâncio Politi Mario José Brandt Carlos Alberto |
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Affiliation: | Departamento de Farmácia, Faculdade de Ciências Farmacêuticas, Universidade de S?o Paulo, S?o Paulo, SP, Brazil. jpsfer@usp.br |
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Abstract: | Allyl 1-naphthyl ethers are useful compounds for different purposes, but reported methods to synthesize them require long reaction times. In this work, we have obtained allyl 1-naphthyl ether in good yield using ultrasonic-assisted methodology in a 1-h reaction. A central composite design was used to obtain a statistical model and a response surface (p<0.05; R(2)=0.970; R(2)(adj)=0.949; R(2)(pred)=0.818) that can predict the optimal conditions to maximize the yield, validated experimentally. |
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