Organometallic photonucleases: synthesis and DNA-cleavage studies of cyclopentadienyl metal-substituted dendrimers designed to increase double-strand scission |
| |
| Authors: | Hurley A L Mohler D L |
| |
| Institution: | Department of Chemistry, Emory University, 1515 Pierce Drive, Atlanta, Georgia 30322, USA. |
| |
| Abstract: | reaction: see text] A series of metal complex-substituted polyamine dendrimers have been synthesized and examined for their ability to cleave plasmid DNA in a double-stranded manner. While photolysis of the dimetallic spermine derivative and the tetrametallic DAB-Am-4 complex led to double-strand scission, in the larger DAB-Am-8 and DAB-Am-16 systems, DNA aggregation/precipitation was the predominant competing process observed. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
