Direct access to heterocyclic scaffolds by new multicomponent Ugi-Smiles couplings |
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| Authors: | El Kaim Laurent Gizolme Marie Grimaud Laurence Oble Julie |
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| Affiliation: | Laboratoire Chimie et Procédés, Ecole Nationale Supérieure de Techniques Avancées, 32 Boulevard Victor, 75739 Paris Cedex 15, France. laurent.elkaim@ensta.fr |
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| Abstract: | New heterocyclic scaffolds can be easily prepared by the coupling of heteroaromatic phenols (pyridines, pyrimidines) with carbonyl compounds, amines, and isocyanides. This transformation related to the Ugi reaction probably involves a Smiles rearrangement. The scope of this methodology is further extended by the successful use of heterocyclic thiols to form highly functionalized thioamides. |
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