PHOTOCHEMICAL INTERACTIONS OF CHLORPROMAZINE WITH PHOSPHOLIPIDS AND CHOLESTEROL IN ARTIFICIAL AND NATURAL MEMBRANES |
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| Authors: | GUY TESTYLIER,GILLES CLEMENT,FRANÇ OIS LETERRIER |
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| Affiliation: | Division de Biophysique du Centre de Recherches du Service de Santédes Armées F 92141 Clarmart, France |
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| Abstract: | Abstract— Dipalmitoylphosphatidyl-choline (DPPC) liposomes do not modify the nature of the photoproducts formed by UV irradiation of chlorpromazine. However, when cholesterol is added to DPPC liposomes, new photoproducts are formed which demonstrate the photoaddition of chlorpromazine to cholesterol. Similar results are obtained with phosphatidyl-serine and phosphatidyl-inositol. The reactivity of irradiated chlorpromazine towards lipidic components of myelin, taken as an example of biological membrane, is also demonstrated. |
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