Asymptotics of a Brownian ratchet for protein translocation

Protein translocation in cells has been modelled by Brownian ratchets  . In such models, the protein diffuses through a nanopore. On one side of the pore, ratcheting molecules bind to the protein and hinder it to diffuse out of the pore. We study a Brownian ratchet by means of a reflected Brownian motion _(Xt)t≥0${\left(X_t\right)}_{t\ge 0}$ with a changing reflection point _(Rt)t≥0${\left(R_t\right)}_{t\ge 0}$. The rate of change of _Rt$R_t$ is γ(_Xt−_Rt)$\gamma (X_t-R_t)$ and the new reflection boundary is distributed uniformly between _Rt−$R_{t-}$ and _Xt$X_t$. The asymptotic speed of the ratchet scales with γ^1/3${\gamma }^{1/3}$ and the asymptotic variance is independent of γ$\gamma$.