Enantioselective synthesis of quaternary stereogenic centers through catalytic asymmetric addition of dimethylzinc to α-ketoesters with chiral cis-cyclopropane-based amide alcohol as ligand |
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| Authors: | Bing Zheng Shicong Hou Zhiyuan Li Hongchao Guo Jiangchun Zhong Min Wang |
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| Institution: | aDepartment of Applied Chemistry, China Agricultural University, Beijing 100193, PR China |
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| Abstract: | A new amino alcohol with a chiral cyclopropane backbone has been developed and used in the catalytic asymmetric diethylzinc addition to various types of α-ketoesters. This cyclopropane-based chiral amino alcohol shows moderate enantioselectivity in the addition of organozinc to α-ketoesters. For dimethylzinc addition to α-ketoesters, up to 81% ee are obtained, respectively. |
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