Human Respiration Under the Condition of Severe Anemia Investigated with the Aid of Fractionation Effects of Oxygen Isotopes |
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| Authors: | H Heller K-D Schuster B O Göbel |
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| Institution: | 1. Physiologisches Institut I der Universit?t Bonn;2. Medizinische Universit?ts-Poliklinik Bonn , Germany |
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| Abstract: | Abstract The dependence of overall fractionation effect of respiration between 16O2 and 16O18O (δIU) on varying levels of hemoglobin concentration within blood is investigated. Experiments are carried out on 6 healthy humans and 6 patients suffering from various degrees of chronic anemia. δIU-values of anemic patients are decreased towards 0‰ meaning that within anemia rates of 16O2? and 16O18O-transport are aligned together more than they are under healthy conditions. On the basis of a resistance model of respiration, it is concluded that within anemia the entire oxygen transport system is more limited by blood flow than it is in healthy humans. This limitation starts to influence respiration far above a hemoglobin concentration of 8 g/100 ml. |
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| Keywords: | anemia blood flow fractionation effects isotope analysis oxygen transport resistance model of respiration respiration stable oxygen isotopes |
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