Isotopenhydrogeologische Untersuchungen Im Bacho-Delta (Vietnam) |
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| Authors: | D Hebert B Hoc H Jordan P Szymczak |
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| Institution: | 1. Hochschule für Bergbau und Geologie Hanoi , Vietnam;2. Bergakademie Freiberg, Institut für Angewandte Physik , Bernhard-von-Cotta-Str. 4, D-O-9200, Freiberg, Deutschland;3. Bergakademie Freiberg , Deutschland |
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| Abstract: | Abstract Abecarnil is a β-carboline with high affinity to benzodiazepine receptors. Synthesis and spectral data of the title compound are presented. 13C3]. Abecarnil was synthesized in a five step synthesis. 13C2]Glycine-isopropylester-hydrochloride was condensed with p-methoxy-benzaldehyde to give N-(p-methoxy-benzyliden)-13C2]glycine-isopropyl-ester. Further reaction with 5-benzyloxy-pseudogramine and the introduction of 13C]formaldehyde in a Pictet-Spengler reaction yielded the intermediate 1,2,3,4-tetrahydro-β-carboline derivative. The following dehydration led to 13C3]Abecarnil in an overall yield of 23% |
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| Keywords: | Carbon 14 deuterium environmental isotopes groundwater isotope hydrology oxygen 18 river delta tritium Vietnam |
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