Oncotripsy: Targeting cancer cells selectively via resonant harmonic excitation |
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| Affiliation: | 1. Department of Bioengineering, University of Texas at Arlington, Arlington, TX 76010, United States;2. Department of Biomedical Technology, King Saud University, Riyadh 12372, Saudi Arabia;3. Department of Biomedical Engineering, University of Miami, Coral Gables, FL 33146, United States;4. Department of Medical Equipment Technology, Majmaah University, Majmaah City 11952, Saudi Arabia;5. Department of Biomedical Engineering, Catholic University of America, Washington, DC 20064, United States;6. Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, United States;7. Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, United States |
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| Abstract: | We investigate a method of selectively targeting cancer cells by means of ultrasound harmonic excitation at their resonance frequency, which we refer to as oncotripsy. The geometric model of the cells takes into account the cytoplasm, nucleus and nucleolus, as well as the plasma membrane and nuclear envelope. Material properties are varied within a pathophysiologically-relevant range. A first modal analysis reveals the existence of a spectral gap between the natural frequencies and, most importantly, resonant growth rates of healthy and cancerous cells. The results of the modal analysis are verified by simulating the fully-nonlinear transient response of healthy and cancerous cells at resonance. The fully nonlinear analysis confirms that cancerous cells can be selectively taken to lysis by the application of carefully tuned ultrasound harmonic excitation while simultaneously leaving healthy cells intact. |
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| Keywords: | Oncotripsy Modal analysis Resonance Cell necrosis |
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