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Spin-lattice relaxation times of bound water—Its determination and implications for tissue discrimination |
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| Authors: | Yoshiki Kaneoke Masahiro Furuse Suguru Inao Katsuyoshi Saso Kazuo Yoshida Yoshimasa Motegi Motomu Mizuno Akira Izawa |
| Affiliation: | a Department of Neurology of Nakatsugawa Municipal General Hospital, Nakatsugawa, Japan b Department of Neurosurgery of Nakatsugawa Municipal General Hospital, Nakatsugawa, Japan c Department of Radiology of Nakatsugawa Municipal General Hospital, Nakatsugawa, Japan d Division of Neurosurgery of Virginia Commonwealth University, Medical College of Virginia, Richmond, Virginia, USA |
| Abstract: | Measurements were made of T1 of bound water (T1b) and bound water fraction () for gelatin solutions and human tissues (sera, brain tumor, cerebral white matter). Bound water fraction in each sample was measured by means of thermal analysis (differential scanning calorimetry: DSC). T1 values were measured by FONAR QED 80-. T1b values were calculated by an equation derived from the fast-exchange two-state model. In the study of gelatin solutions, the relationship between T1 and water content differed depending on the sort of solutions. This was considered to be due to differences in T1b values. In each biological tissue the values of T1b and had different distributions. These results indicate that values of T1b and for biological tissues may be altered in correspondence to the changes in pathophysiological states in those tissues. |
| Keywords: | T1 of bound water Tissue T1 Bound water fraction Thermal analysis |
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