| THE SYNTHESIS OF PROTECTIVE FRAGMENTS OF α-HUMAN ATRIAL NATRIURETIC POLYPEPTIDE (α-hANP) |
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| 引用本文： | 蔡孟深,彭师奇,程铁明,戴敦华,王少农,李金祥,张京莉,丛阳,梁伟升,王融,杨生生,陈双环,吴小东,张艾卓,J.K.CHANG.THE SYNTHESIS OF PROTECTIVE FRAGMENTS OF α-HUMAN ATRIAL NATRIURETIC POLYPEPTIDE (α-hANP)[J].中国科学B辑(英文版),1988(4). |
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| 作者姓名： | 蔡孟深 彭师奇 程铁明 戴敦华 王少农 李金祥 张京莉 丛阳 梁伟升 王融 杨生生 陈双环 吴小东 张艾卓 J.K.CHANG |
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| 作者单位： | Department of Organic Chemistry，Beijing Medical University，Department of Organic Chemistry，Beijing Medical University，Department of Organic Chemistry，Beijing Medical University，Department of Organic Chemistry，Beijing Medical University，Department of Organic Chemistry，Beijing Medical University，Department of Organic Chemistry，Beijing Medical University，Department of Organic Chemistry，Beijing Medical University，Department of Organic Chemistry，Beijing Medical University，Department of Organic Chemistry，Beijing Medical University，Department of Organic Chemistry，Beijing Medical University，Department of Organic Chemistry，Beijing Medical University，Department of Organic Chemistry，Beijing Medical University，Department of Organic Chemistry，Beijing Medical University，Department of Organic Chemistry，Beijing Medical University，Department of Organic Chemistry，Beijing Medical University |
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| 摘 要： | In this paper the synthesis of α-human atrial natriuretic polypeptide fragments (positions, 1-4, 5-10, 11-16, 17-22, 23-28) by solution method is reported. In the synthesis of some peptides, the re-sults from mixed anhydride procedure and active ester procedure are compared. In the synthesis of otherpeptides, the effects of reaction temperature, basicity of catalyst, and reaction time on the specific rota-tions and yields of these compounds are observed. The sequence of amino acids of all the protective poly-peptides is confirmed by FAB-MS.
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