| X-Ray Diffraction and NMR Study of Inclusion Complex of Podophyllotoxin with β-Cyclodextrin |
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| 作者姓名： | Xue Yi MA Zhi Xin LIAO Yun ZEN Hua Dong XIU Ru LIU and Yao Zu CHEN |
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| 作者单位： | Department of Chemistry，National Laboratory of Applied Organic Chemistry，Lanzhou University，Lanzhou 730000 |
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| 摘 要： | Podophyllotoxin(Figurel)isalignan,naturallyoccurringinrootsandrhizomesofPodophyllumemodiWall.var.ChineseSprague'.Thiscompoundisclinicallyusedtotreatseveraltypesofcancer2.However,asadrug,itisrestraintedduetoitshightoxicityandsideeffecttohumanbody.Wehavepreparedtheinclusioncomplexofpodophyllotoxinwith0-cyclodextrin(Figure2)inordertodecreasetoxicityandincreasesolubilityofpodophyllotoxin.ThestrUctureoftheinclusioncomplexofthepodophyllotoxinwith0-cyclodextrinhavebeenstudiedbythemethodsofX-raydi…
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| 关 键 词： | Podophyllum bexan drum podophyllotoxin β-cyclodextrin inclusion complex X-Ray NMR |
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