Synthesis of trisubstituted imidazoles by palladium-catalyzed cyclization of O-pentafluorobenzoylamidoximes: application to amino acid mimetics with a C-terminal imidazole |
| |
| Authors: | Zaman Shazia Mitsuru Kitamura Abell Andrew D |
| |
| Affiliation: | Department of Chemistry, University of Canterbury, Private Bag 4800, Christchurch, New Zealand. |
| |
| Abstract: | 1-Benzyl-4-methylimidazoles with a range of substituents at the 2-position are prepared from O-pentafluorobenzoylamidoximes on treatment with catalytic amounts of Pd(PPh3)4 and triethylamine. The sequence provides access to optically active amino acid mimetics with a C-terminal imidazole. [structure: see text] |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
