| 穿心莲内酯硫酸酯化反应体系中四个新的衍生物的分离与表征 |
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| 引用本文： | 许卉,王功富,韩飞,刘珂,杨小玲,唐春山. 穿心莲内酯硫酸酯化反应体系中四个新的衍生物的分离与表征[J]. 化学学报, 2009, 67(3): 261-265 |
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| 作者姓名： | 许卉 王功富 韩飞 刘珂 杨小玲 唐春山 |
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| 作者单位： | 烟台大学药学院,烟台,264005;江西青峰药业有限公司,赣州,341000 |
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| 摘 要： | 通过色谱方法, 从复杂的穿心莲内酯硫酸酯化反应体系中分离获得4个新的穿心莲内酯衍生物, 应用谱学方法进行了表征. 主要利用1H NMR, 13C NMR, DEPT, 1H-1H COSY, HSQC, HMBC及NOSEY等1D和2D NMR技术, 并通过与母体化合物NMR数据的对比分析, 鉴定这4个化合物分别为3,19-二羟基-8,11,13-赖百当三烯-15,16-内酯(1), 3-羟基-8,11,13-赖百当三烯-15,16-内酯-19-硫酸酯(2), 8,11,13-赖百当三烯-15,16-内酯-3,19-二硫酸酯(3), 3-羟基- 8(R)-12(S)-8(12)-环氧-13-赖百当烯-15,16-内酯-19-硫酸酯(4).
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| 关 键 词： | 穿心莲内酯 硫酸酯化反应 核磁共振谱 表征 |
| 收稿时间： | 2008-05-23 |
| 修稿时间： | 2008-08-20 |
Isolation and Characterization of Four New Derivatives of Andrographolide from Sulfonation System |
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| Xu Hui,Wang Gongfu,Han Fei,Liu Ke,Yang Xiaoling,Tang Chunshan. Isolation and Characterization of Four New Derivatives of Andrographolide from Sulfonation System[J]. Acta Chimica Sinica, 2009, 67(3): 261-265 |
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| Authors: | Xu Hui Wang Gongfu Han Fei Liu Ke Yang Xiaoling Tang Chunshan |
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| Affiliation: | (a School of Pharmacy, Yantai University, Yantai 264005) (b Qingfeng Pharm Co. Ltd., Ganzhou 341000) |
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| Abstract: | Four new derivatives of andrographolide were chromatographically isolated from its complicated sulfonation product mixture,and then characterized by spectroscopic methods.Together with 1D and 2D NMR technology,including 1H NMR,13C NMR,DEPT,1H-1H COSY,HSQC,HMBC and NOSEY,and comparison of the NMR data with those of the parent compound,the structures of all the four derivatives were elucidated as 3,19-dihydroxy-labdanum-8,11,13-trien-15,16-olide(1),3-hydroxy-labdanum-8,11,13-trien-15,16-olide-19-sulfuric este... |
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| Keywords: | andrographolide sulfonating reaction nuclear magnetic resonance characterization |
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