Chemical Biology Studies on Molecular Diversity of Annonaceous Acetogenins

Annonaceous acetogenins, isolated from the Annonaceae plants, have been attracting worldwide attention in recent years due to their biological activities, especially as growth inhibitors of certain tumor cells 1]. They have been shown to function by blocking complex I in mitochondria 2] as well as ubiquinone-linked NADPH oxidase in the cells of specific tumor cell lines, including some multidrug-resistant ones 3]. These features make these acetogenins excellent leads for the new antitumor…