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Synthetic approaches to thienamycin: Carbon-carbon bond formation at C-4 of azetidin-2-ones |
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| Authors: | Paul J. Reider Richard Rayford Edward J.J. Grabowski |
| Affiliation: | Merck Sharp & Dohme Research Laboratories P.O. Box 2000 Rahway, New Jersey 07065 U.S.A. |
| Abstract: | A mild and efficient method of β-lactam alkylation has been achieved using 4-acetoxy-2-azetidinone and a variety of silyl enol ethers. |
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