Reduction of β-ketosulfoxides : a highly efficient asymmetric synthesis of both enantiomers of methyl carbinols from the corresponding esters |
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| Authors: | Guy Solladié Christine Greck Gilles Demailly Arlette Solladié-Cavallo |
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| Affiliation: | Laboratoire de Stéréochimie de l''Ecole Nationale Supérieure de Chimie (ERA 687), Université Louis Pasteur, 67008 Strasbourg - France |
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| Abstract: | It is shown that reductions of β-ketosulfoxides of identical chirality (R) at sulfur, lead to reduction products of opposite stereochemistry according to the reducing agent used. The high enantiomeric excesses obtained (80 to 100%) provide a general route to both enantiomers of methylcarbinols from the corresponding esters. |
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