One electron transfer mechanism in the enzymatic oxygenation of sulfoxide to sulfone promoted by a reconstituted system with purified cytochrome p-450 |
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| Authors: | Yoshihito Watanabe Takashi Iyanagi Shigeru Oae |
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| Institution: | Department of Chemistry, The University of Tsukuba, Sakura mura, Ibaraki 305, Japan;Divison of Biochemistry, School of Medicine, The University of Tsukuba, Ibaraki 305, Japan |
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| Abstract: | A kinetic study on enzymatic S-oxygenation of sulfoxides to sulfones was carried out by a reconstited system with purified cytochrome P-450. A linear correlation observed between log(Vmax)'s and the one-electron oxidation potentials of sulfoxides suggests that the oxygenation of sulfoxides proceeds via one electron transfer process to the active “oxenoid” intermediate of the enzyme. |
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