Nuclear analogs of β-lactam antibiotics 8. Stereospecific synthesis of a C-3 methoxylated monocyclic s-lactam期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Nuclear analogs of β-lactam antibiotics 8. Stereospecific synthesis of a C-3 methoxylated monocyclic s-lactam

Authors:	Robert M DeMarinis William M Bryan

Institution:	Research and Development Division Smith Kline and French Laboratories Philadelphia, Pennsylvania 19101 U.S.A.

Abstract:	Methoxylation of $1$ (R = PhOCH₂CO) occurred stereospecifically from the α-face as determined by x-ray crystallography to provide $2$ which was converted to $4$ whose $in$ $vitro$ antimicrobial activity was determined.

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