Stereoselective synthesis of (2s,3s,4r)-4-amino-3-hydroxy-2-methyl-pentanoic acid,an amino acid constituent of bleomycin,by aldold condensation)期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Stereoselective synthesis of (2s,3s,4r)-4-amino-3-hydroxy-2-methyl-pentanoic acid,an amino acid constituent of bleomycin,by aldold condensation)

Authors:	Masatoshi Narita Masami Otsuka Susumu Kobayashi Masaji Ohno Yoji Umezawa Hajime Morishima Sei-ichi Saito Tomohisa Takita Hamao Umezawa

Affiliation:	Faculty of Pharmaceutical Sciences, University of Tokyo Bunkyo-ku, Tokyo 113, Japan;Institute of Microbial Chemistry Shinagawa-ku, Tokyo 141, Japan

Abstract:	(2S,3S,4R)-4-Amino-3-hydroxy-2-methylpentanoic acid, a novel amino acid constituent of bleomycin, has been synthesized stereoselectively through aldol condensation of (R)-2-aminopropionaldehyde derivatives and E-vinyloxyboranes.

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