Stereoselective synthesis of (2s,3s,4r)-4-amino-3-hydroxy-2-methyl-pentanoic acid,an amino acid constituent of bleomycin,by aldold condensation) |
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| Authors: | Masatoshi Narita Masami Otsuka Susumu Kobayashi Masaji Ohno Yoji Umezawa Hajime Morishima Sei-ichi Saito Tomohisa Takita Hamao Umezawa |
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| Institution: | Faculty of Pharmaceutical Sciences, University of Tokyo Bunkyo-ku, Tokyo 113, Japan;Institute of Microbial Chemistry Shinagawa-ku, Tokyo 141, Japan |
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| Abstract: | (2S,3S,4R)-4-Amino-3-hydroxy-2-methylpentanoic acid, a novel amino acid constituent of bleomycin, has been synthesized stereoselectively through aldol condensation of (R)-2-aminopropionaldehyde derivatives and E-vinyloxyboranes. |
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