An efficient synthesis of 5-diethoxymethylimidazole-4-carboxylate,a potential precursor for various imidazole derivatives |
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| Authors: | Teiichi Murakami Masami Otsuka Masaji Ohno |
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| Affiliation: | Faculty of Pharmaceutical Sciences, University of Tokyo Hongo, Bunkyo-ku, Tokyo 113, Japan |
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| Abstract: | Anionic cycloaddition of methyl isocyanoacetate to diethoxyacetonitrile afforded methyl 5-diethoxymethylimidazole-4-carboxylate, a useful imidazole nucleus with two different functional groups. |
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