Reductive alkylation of 2-methoxybenzoic acid derivatives |
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| Authors: | James M Hook Lewis N Mander Michael Woolias |
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| Institution: | Research School of Chemistry, Australian National University P.O. Box 4, Canberra, A.C.T. 2600, Australia |
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| Abstract: | Metal-ammonia reduction followed by in situ alkylation of 2-methoxybenzoic acids often results in substantial loss of the methoxy substituent; reduction of the carboxylate salts or esters, however, suppresses this side reaction and good to excellent yields of desired products are then obtained. |
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