A new synthesis of deglyco-bleomycin A2 aiming at the total synthesis of bleomycin |
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| Authors: | Sei-ichi Saito Yoji Umezawa Hajime Morishima Tomohisa Takita Hamao Umezawa Masatoshi Narita Masami Otsuka Susumu Kobayashi Masaji Ohno |
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| Affiliation: | Institute of Microbial Chemistry Shinagawa-ku, Tokyo 141, Japan;Faculty of Pharmaceutical Sciences, University of Tokyo Bunkyo-ku, Tokyo 113, Japan |
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| Abstract: | An improved route to synthesize deglyco-bleomycin A2, the aglycon of bleomycin A2, aiming at the total synthesis of bleomycin is described. The new route is characterized by the stepwise elongation of the amino acid constituents and the use of a thiol ester obtained by aldol condensation. |
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