Conversion of epoxides to 1,3-dioxolanes catalyzed by tin(II) chloride |
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| Authors: | Vyvyan James R Meyer Jennifer A Meyer Korin D |
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| Institution: | Department of Chemistry, Western Washington University, Bellingham, WA 98225-9150, USA. vyvyan@chem.wwu.edu |
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| Abstract: | Anhydrous tin(II) chloride is an efficient catalyst for the reaction of epoxides with acetone to prepare 2,2-dimethyl-1,3-dioxolanes (acetonides) in good to excellent yields. Mono-, di-, and trisubstituted epoxides participate equally well in this diastereospecific reaction. The use of single enantiomer epoxides under the reported conditions results in significant erosion of optical activity. |
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